Metabolism/Diabetes (Leonardo)
CFDRC is developing sophisticated software tools and mathematical models to build a virtual diabetic human, dubbed Diabetic Leonardo. This diabetes simulator will be capable of learning the specific physiological characteristics of the patient/user, daily food intake, sleeping, exercise and stress levels and then use that knowledge to predict blood glucose concentrations several hours into the future as he goes through daily life activities. Leonardo supports normal, type I, type II, and pre-diabetes patients.
Diabetic Leonardo is an ambitious goal that draws heavily on the knowledge of countless scientists inside and outside of CFDRC working on devising clever mathematical representations for the different parts of the body (e.g. liver, arteries, pancreas, etc.) By carefully assembling these parts together we have created a virtual diabetic human that behaves like a real one. This technology will be able to improve the lives of diabetics both as educational tools to teach patients how to take better care of themselves, and as insulin pump control algorithms that predict how much insulin is needed at any given time.
The responses of Type I, Type II, pre-diabetes (impaired glucose tolerance), as well as normal patients (symbols) after a standard oral glucose tolerance test (OGTT) were all reproduced by Diabetic Leonardo (lines).
